CALL FOR PAPERS Sex Differences in Renal and Cardiovascular Function: Physiology and Pathophysiology Impact of androgen-induced oxidative stress on hypertension in male SHR

Impact of androgen-induced oxidative stress on hypertension in male SHR.

Men have higher blood pressure than women, and androgens and oxidative stress have been implicated as playing roles in this sexual dimorphism. The spontaneously hypertensive rat (SHR) is an animal model of both androgen- and oxidative stress-mediated hypertension. Therefore, the present studies were performed to test the hypothesis that androgens cause hypertension in SHR in part by stimulating...

Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats.

NADPH oxidase has been implicated in ANG II-induced oxidative stress and hypertension in males; however, the contribution of oxidative stress to ANG II hypertension in females is unknown. In the present study, we tested the hypothesis that greater antioxidant capacity in female spontaneously hypertensive rats (SHR) blunts ANG II-induced oxidative stress and hypertension relative to males. Whole...

In Focus CALL FOR PAPERS Sex Differences in Renal and Cardiovascular Function: Physiology and Pathophysiology Physiological and molecular mechanisms governing sexual dimorphism of kidney, cardiac, and vascular function

IT IS WELL ESTABLISHED THAT cardiovascular disease is a leading cause of death in developed countries, but it is less well known that more women than men die of cardiovascular disease, although these deaths are delayed by 10 yr (7, 17). It is becoming evident that there is considerable sexual dimorphism in the pathogenesis of cardiovascular disease. Thus findings from past studies, mostly in ma...

Impact of androgen-induced oxidative stress on hypertension in male SHR by

Sex and sex hormones influence the development of albuminuria and renal macrophage infiltration in spontaneously hypertensive rats.

There is a sex difference in hypertensive renal injury, with men experiencing greater severity and a more rapid progression of renal disease than women; however, the molecular mechanisms protecting against renal injury in women are unknown. The goal of this study was to determine whether sex hormones modulate blood pressure and the progression of albuminuria during the developmental phase of hy...